Abstract: Objective To explore the influencing factors of preoperative ^99mTc-MIBI single-photon emission computed tomography/computed tomography（SPECT/CT） in patients with suspected primary hyperparathyroidism (PHPT). Methods  A total of 257 patients with suspected PHPT who underwent preoperative MIBI SPECT/CT from January 2019 to August 2023 were retrospectively reviewed. The laboratory examination,pathological features,and imaging features between the positive and negative MIBI SPECT/CT groups were compared to each other. Multivariate Logistic regression analysis was used to identify the influencing factors of MIBI SPECT/CT results.  Results  The serum total calcium,parathyroid hormone（PTH）,and alkaline phosphatase（ALP） levels were significantly increased in the positive group than the negative group (P < 0.05); The pathological type,maximum diameter,volume,and location of the lesion showed statistically significant differences between the two groups (P < 0.05). Logistic regression analysis showed that preoperative serum PTH levels,pathological type,location,and maximum diameter of lesions were significantly correlated with positive MIBI SPECT/CT (P < 0.05). Conclusion  The preoperative MIBI SPECT/CT in patients with suspected PHPT were affected by multiple factors. The preoperative serum PTH level,pathological type,location and the maximum diameter of the lesion were independent factors for MIBI SPECT/CT. 

Key words: primary hyperparathyroidism (PHPT), ^99mTc-methoxyisobutylisonitrile(MIBI), single-photon emission computed tomography/computed tomography（SPECT/CT）